What is Evana® Heavy Period Relief 500 mg Tablets?

Evana is a pharmacy-only treatment that contains 500mg tranexamic acid for the reduction of HMB over several cycles.6 The active ingredient in Evana is recommended by NICE as a first-line non-hormonal treatment option for HMB.2,9 Indeed, it contains the ONLY active ingredient licensed for OTC use in HMB management.9 

An image of a packet of Evana

How does Evana® work in HMB?

Women with HMB have been found to have increased fibrinolytic activity in their menstrual blood.10,13 This causes accelerated degradation of the fibrin clot that forms to induce haemostasis13– see Figure 1. This increased fibrinolytic activity results in increased blood loss when the endometrium is shed during menstruation.13 

Figure 1 : What happens in fibrinolysis14 
Figure 2: How tranexamic acid works to inhibit fibrinolysis14 

The tranexamic acid in Evana is an anti-fibrinolytic agent, which is a potent competitive inhibitor of the activation of plasminogen to plasmin.6 see Figure 2. Tranexamic acid reversibly blocks lysine binding sites on plasminogen, which prevents plasmin interacting with lysine residues on the fibrin polymer.  This blocking results in a deceleration in subsequent fibrin degradation, leading to a slowing in clot dissolution and, therefore, menstrual bleeding.8,10

How effective is Evana® in managing HMB?

 
Data show that the active ingredient in Evana can reduce menstrual bleeding by up to 60%.7 Most women will see a significant reduction in HMB within the first cycle of use15 but for a small proportion it may take several cycles for Evana to significantly reduce HMB.6,15 For example, in one study, after the first cycle of tranexamic acid use, 87% of women perceived a decreased or strongly decreased volume of menstrual bleeding, rising to 94% of users after the third cycle of use.15 

Benefits on Menstrual Bleeding

  • 94% of women experienced decreased volume of bleeding*15
  • 80% of women were satisfied with tranexamic acid treatment*15

Benefits on quality life

  • 83% of women had improved leakage/flooding16
  • 67% had an improved social life16
  • 46% had an improved sex life16

Additional customer benefits

  • Non-hormonal option2
  • No impact on fertility17

*after the third menstrual cycle with tranexamic acid treatment

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